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The film unfolds in 1993, with renowned journalist Virginia Vallejo escaping Colombia under dire circumstances. She is portrayed as a strong and intelligent woman, whose life has been irrevocably altered by Escobar. As she arrives in the United States, we see her treat her situation with a mix of humor and sorrow. She is escorted by DEA agent Shepard, who outlines the precariousness of her safety. Virginia's thoughts drift back to her past, setting the stage for a series of flashbacks that showcase how she became entwined with one of the world's most notorious criminals.