Actually it is more difficult for smaller cap companies to do something like this, because their operations require all the capital they can get. MicroStrategy was in a good position because they didn’t need more money for core business operations and had to figure out how to preserve the value of half a billion in their treasury.
For Microsoft to invest a few billions in bitcoin wouldn’t change anything. It wouldn’t even be noticeable. Just another R&D expense. However, they would start participating in the technology.
They will surely regret this decision just like many other bad decisions they have made over the years.
That said, I think shareholders of big companies will keep voting against bitcoin, because if big companies start getting involved there won’t be many left at desired prices for them to buy.
For example, Blackrock probably prefers to have more bitcoins under their management, rather than Microsoft or Amazon, although Blackrock is invested in most big companies.