I have been on both Bittrex and Poloniex. The coins on both exchanges you can expect Bittrex to follow Poloniex.
I traded well on Bittrex with the coins that are not on Polo. I recommend you pick one or some and watch them trade for the patterns from the whales for a while. After you decide you are comfortable with a coin, place a low buy and wait until it fills. Sometimes you hit when it is pumping, other times you miss your projection but if place a sell order and leave it...you will have success.
Now coins that are on Poloniex and Bittrex is easier to trade. Open up the Poloniex website and watch the trading there. Bittrex will follow them and you essentially trade like you are on Poloniex. Also, you find the spreads to be bigger and trading much slower unless is a high volume.
I find it easier to trade on Bittrex and have less stress about performance like i do at Poloniex. Hope that helps.