Single-use addresses are easy to detect as they only have one incoming transaction and one outgoing transaction... Just check which wallet addresses are used only once together and you can see a pattern... As wallet addresses are generated from same private key, you can eventually see which addresses are for same user. You need to use Base58 decode on the wallet addresses before you can compare them as you need bit-wise compare.
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Is it possible to do that chain wide to get an idea of the total number of bitcoin wallets?
I think it is possible after figuring out the bit mask of the public keys of wallets derived from same private key... I know how it can be done in CryptoNight coins, but not how it can be done in scrypt coins that only use one private key instead of two.