Is this accurate?
"Critical Preprint (15 Apr 2025): Japanese scientists sound the alarm—repeated mRNA COVID-19 vaccinations drastically increase IgG4 levels, crippling cancer immunity and fueling aggressive tumor growth. Disturbingly, this correlates with markedly poorer survival rates in pancreatic cancer patients.
"Repeated COVID-19 Vaccination as a Poor Prognostic Factor in Pancreatic Cancer: A Retrospective, Single-Center Cohort Study"
"We retrospectively examined the effect of vaccination on survival in 272 PC patients diagnosed at our hospital from Jan 2018 to Nov 2023 and analyzed prognostic factors, including IgG4 levels in 96 PC patients"
"Patient outcomes had improved each year by 2020; however, it began to deteriorate in 2021 and outcomes in 2022-2023 were significantly worse than those in 2018-2021"
"The overall survival (OS) of PC patients was shortened in those vaccinated three times or more, and the total serum IgG4 levels increased with the number of vaccinations."
"Of note, OS was significantly shorter in the high IgG4 group, and Foxp3-positive cells in the tumor tissues were increased."
"Repeated vaccinations increased spike-specific IgG4 levels, and a positive correlation was observed between spike-specific IgG4 and total IgG4."
"These findings highlight repeated vaccination as a poor prognostic factor in PC patients and suggest that IgG4 is induced by repeated vaccination and may be associated with a poor prognosis in these patients."
🔗 https://www.preprints.org/frontend/manuscript/4596461045ab13dc5db9d869b018d540/download_pub