Nice reference to Popper in terms of "falsification" . I agree it does suck to be sad , however prior to sucking it up there does need to be a moment of this sucks and I am gonna confront it and deal with it. Once that is done you can get back to "normal" life. If you get stuck in that phase your friends will get bored of it but they wont tell you , they will just stop calling !
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Yeap, this is why depression is an epidemic in the western world and not across the entirety of the human species. For the very reasons I mentioned. It is a cultural meme.
Because it's not universal it doesn't mean it is not an illness. You lost a logic there. There are psychiatric ilnesses which are culturally specific.