Some 900,000 people have been forced from their homes and shelters in northwestern Syria since December, leaving huge numbers to sleep rough in the bitter cold.
The United Nations said half a million among them were children, some of whom have died of exposure in snow-covered camps.
It warned that the crisis could worsen unless a ceasefire is reached.
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"Over the past four days alone, some 43,000 newly displaced people have fled western Aleppo where fighting has been particularly fierce," UN spokesman David Swanson told AFP on Tuesday.
A staggering 300,000 people have been displaced since the beginning of February, he said.
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