Article originally published on Activist Post
New scientific research is causing scientists to rethink what they believe about the static nature of genes. What do these discoveries mean for a species increasingly facing environmental and political calamity?
Ongoing discoveries regarding how environmental factors can affect life on the genetic level are causing many scientists and researchers to rethink the notion that the genetic makeup of an individual is static and unchanging. Most recently, a team of researchers with Tufts University has found evidence which suggests stress or mistreatment during childhood can lead to genetic changes which are passed down to the victim’s children and grandchildren. Larry Feig and his team have shown that inducing stress on mice can lead to genetic changes which are imprinted on the sperm. This same effect has been found in male humans as well.
Feig’s study, “Reduced levels of miRNAs 449 and 34 in sperm of mice and men exposed to early life stress,” published in Translational Psychiatry, asked 28 men to provide a sperm sample and complete the Adverse Childhood Experience (ACE) questionnaire. The questionnaire is designed to determine the degree of abusive and/or dysfunctional family experiences an individual experience as a child. These experiences increase the risk of developing future psychological and physical disorders.
The researchers also began looking for evidence of small molecules called micro-RNAs.”Their job is to bind to another molecule called messenger RNA, whose task in turn is to ferry information read from a gene to the cellular factories that create the required protein,” The Economist explains. “Micro-RNA renders messenger RNA inactive, reducing the activity of the gene in question—and it can travel in sperm alongside DNA.” This alteration by mircro-RNA can lead to epigenetic changes which are apparently passed on to offspring along with the genes themselves. This means an individual’s life experiences can have an effect on their children.
Upon screening the men’s sperm the researchers found two types of micro-RNAs, miR-34 and miR-449, were as much as 100 times lower in samples from abused men. The team also purposefully stressed mice by moving them to new cages with new mice throughout their childhood. The researchers found that stressed male mice also had lower levels of miR-34 and miR-449 in their sperm. Even upon mating with unstressed females the embryos had similarly low levels of the two micro-RNA. The sperm from the male offspring also had the same low levels. These changes were found in the following generations even when they had not experienced any abuse or stress themselves.
“Since offspring of men exposed to early life trauma have elevated risks for psychological disorders, these findings raise the possibility that a portion of this risk may be derived from epigenetic regulation of these sperm miRNAs,” the researchers write. The new study also indicates that female offspring of stressed male mice will likely be more anxious and less sociable. These results show that the effects last for at least three generations. The researchers plan to do the study again with a larger group of men and possibly other family members.
So what exactly is Epigenetics?
What is Epigenetics? defines the term as “in addition to changes in genetic sequence,” but acknowledges the word has “evolved to include any process that alters gene activity without changing the DNA sequence, and leads to modifications that can be transmitted to daughter cells.” As the Tufts University study has shown, these genetic changes were passed down via sperm and embryo to the following generations even without being exposed to the same trauma as the parent or grandparent.
Epigenetics currently sits on the fence between accepted mainstream science and New Age panacea. Scientists who have been hesitant to admit that genes are not static are being forced to rethink their positions, while spiritualists and believers in the law of attraction swear that epigenetics proves that our state of mind directly determines our physical health and body. While the research has been taking place for decades, it is only now coming to be understood that our individual experiences and environmental factors can change us on the genetic level. This could come from not only psychological or emotional trauma, but also outside factors like chemicals in our environment.
In a 2006 article published in Environmental Health Perspectives, researchers write, “Known or suspected drivers behind epigenetic processes include many agents, including heavy metals, pesticides, diesel exhaust, tobacco smoke, polycyclic aromatic hydrocarbons, hormones, radioactivity, viruses, bacteria, and basic nutrients.” This reemphasizes the need for a healthy lifestyle and diet free of tobacco smoke, hormones, heavy metals, and pesticides.
In addition, in 2005, Michael Skinner, a professor of molecular biosciences and director of the Center for Reproductive Biology at Washington State University, showed that pregnant rats exposed to high levels of the insecticide methoxychlor lead to decreased sperm production and increased male infertility in the male children. Skinner and team also found DNA alteration with two genes. Even in the absence of additional pesticide exposure, these adverse effects lasted in about 90% of the males in the following four generations. In February of this year, researchers from Washington State University studied the epigenetic effects of the now-banned pesticide DDT. The team found that a wide range of epigenetic changes resulted from DDT exposure to mice across three generations.
Researchers are beginning to believe that these epigenetic changes may be “remembered” through a phenomena known as transgenerational inheritance. As What is Epigenetics? notes, “There is currently a large debate in the field as to precisely what epigenetic modifications can be inherited and if these pass down to the third generation.”
What will epigenetics tell us about the human species’ capacity to heal from or completely avoid trauma? Does it change the way you look at the world or the way you treat another individual if you know that your actions could affect them on the genetic level? Does it alter the way you view your own trauma?
I believe an understanding of epigenetics should encourage every individual to rethink the way they live their very lives. With epigenetics in mind, we should rethink the way we treat children and the way we communicate with other people, in general. I am a firm believer in peaceful parenting and the fact that hitting children can affect their level of gray matter in the brain, but it also likely causes stress that leads to epigenetic changes, possibly even negative health effects. In addition, learning to use tools like non-violent communication can be a great way to learn to connect with someone in a respectful and compassionate, but firm manner without causing unnecessary harm or frustration.
Also, we must take a moment to think about the idea that it is not only negative or harmful experiences which can be imprinted on our genes. Through “transgenerational inheritance” we might also inherit positive emotional, psychological, and physical attributes. This makes it of utmost importance for each of us to focus on working through our own emotional trauma in pursuit of healing and closure. By doing so we are likely improving the chances that our future progeny will not inherit genes filled with trauma, stress, abuse, and illness.
Are you a geneticist, Mr. @dbroze? I like your article! It is great! ^_^
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Fantastic article man. Sometimes we can feel our own healing but seeing the nonphysical aspects of healing manifest themselves physically in our biology helps to articulate the true potential to change ourselves. I've never vibed with the "you are who you are" or the "these are the cards you were dealt" outlook. There is so much potential in the world and we have so many days to cultivate change within our on lives and bodies. Love that it's coming to light in the science/medical community.
See ya soon : )