I made a pretty simple tutorial on how I tend to approach spriting: https://steemit.com/anime/@retrauxjunk/dragon-maid-spriting-tutorial.
I typically just work in MS Paint since that's what I'm used to, but I've been meaning to learn Pro Motion (https://www.cosmigo.com/). It's pretty popular among professionals, like Way Forward and Yacht Club Games.
Thank you very much i'm going to look into this