As I say, for it's time and innovation it certainly deserves to stand in the hall of fame for gaming breakthroughs, but the game itself is not as endearing as more recent titles like Neverwinter nights that was released slightly after.
If you asked me about Neverwinter, I can tell you all about the lore, history and story of the game...
I really struggle to remember much about the game direction from System Shock, even though I played it to death.
It all depends on your personal preferences, some people like fantasy more, for me if there is a good story and atmosphere mixed with excellent gameplay, theme is not that important. I too know a lot about Neverwinter Nights, I played every game in the series including expansions :)