Schizophrenia seems to be caused by disordered nmda receptor activation. From a lack of co-agonists d-serine and glycine. Major breakthroughs in treatment have been provided by sarcosine aka n-methylglycine which is a reverse agonist at the nmda receptor glycine site(so named because they hadn't known d-serine was a molecule with higher specificity). Sarcosine however must be dosed repeatedly throughout the day so as to be effective and therefore extended release formulations have been devised. The name of which currently escapes me.
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Thanks @drabs for the response..nicely explained the pathophysiology & t/t
Certaintly not the only pathophysiological occurances in schizophrenia though nor the best treatment of the underlying pathology: excess production of quinolinic acid(an nmda agonist) during the production of niacin, worsening of symptoms by lack of magnesium known to block nmda channels. Again worsened by zinc deficiency which also blocks nmda activity. That pyroluria(not generally accepted by mainstream medicine however it most certainly seems to be occuring), a condition whereby both zinc and b6 are excreted bound to an altered heme metabolite; perhaps a bodily mechanism to prevent ordered thinking and excess energy metabolism(oxidation) during times of specific nutrient inavailabilities. A condition which is likely involved with schizophrenia. If we followed old patterns it would be unlikely we try that new food or consider that food we tried many months ago as a means of recovery/necessity. In many cultures mysticism was an ability to form connections and understand concepts which were generally overlooked by the community. The learning of which governed by nmda activity and d-aspartate among many other factors modulating nmda activity. The "biology of kundalini" begins to speak upon the biological mechanisms which govern schizophrenia and mysticism, the former being those who are further lacking in nutrient availability.