I know what you mean. I just moved from the Arkansas delta and it's one of the hot spots for cancer. It was very much "normal". The farming chemicals such as Roundup are likely to blame for the higher cancer rates there. The farmers, once they get to a certain age usually get cancer, too. Almost 50% of the older people it seemed had gotten cancer at least once there. I'm glad I got away from those farm chemicals to say the least...
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I live in northeast Louisiana which is the same area and yep most of the farmers die early of cancer.