Thanks for this detailed response. Taking me back to chemistry/pharmacology is always a good thing (especially now that I can prescribe). Makes a lot of sense on how blocking (competitively I presume) would be much easier.
That is the million dollar drug though.
The DNA part seems even harder in a way, but if the molecule is too small to allosterically bind... maybe that would be an easier way.
Hydrating seems like a good idea, but maybe we will never find the cure!
Its not a factor of size, but rather the possibility of binding anywhere actually inducing a change which affects enzyme activity. It may not be physically possible.
Good to know! Thanks a lot.