Going the first fixture, Tottenham looks like the most likely team to taste their first defeat considering their playing a more better side in Manchester city.
Also with top forward Harry Kane set to depart, they will prove little threat in the league they find a situation replacement or Heuyin son mying steps up.
The leceister vs wolves also seems like a game the foxes could lose considering the tough the Wolverhampton side seems to give other top five EPL teams.
So for me it's Tottenham Hotspur or leciester city to lose on the first day of the 2021/2022 English premiership season.