I think so too. I'd see blood donation, raising money for fighting the top killers (like cancer, heart disease, Alzheimer's, lou gehrig's disease, etc), and helping the poor would all be among worthy causes. Things that help people and help society, mainly. But that's me. I'm sure your list might vary. That said, I don't know if it's a cut or dry issue and is more case by case.
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Case by case for me...I don't have a lot of faith in 'charities' as it seems so many of them do inappropriate things with the funds the
extortcollect from others.