Ha! Yeah, I have seen a few "adverse effects" for others at work functions. Long ago had one or two small ones myself and now stay away from it :-)
I just take the you do you approach with these folks and it usually works. If they are far into their cups and irrational, I just run away like a little child ;-)
Reasoning with a drunk is tiresome. I think everyone loves me when I am drunk! Hahaha! Turns out they don't!
Interesting how a drunk person thinks they're more interesting, funny, likeable or whatever...typically they are not.