It would be a bit rough and the payout for surviving a run would have to be worth having to pay for every new run after a defeat. But it could happen! Maybe with a system similar to Enjin where items and gear is only in the game until a player mints it into an NFT to sell/trade for crypto. Though that might turn the market into a "Play to win' model and that's already a rough thing to step away from when creating a game on the blockchain.
It's an interesting thought and I think you should keep your eyes out for something close to a roguelike. Thanks for sharing!