the time factor affects me, when I go back to the game I forget what I had to do.
This is a big problem for me with games that use all the buttons on the controller. If I take just a few days break it means that once I return I am not going to remember the buttons. One of the worst things I can do to myself is quit at a tough boss battle. If i do that I basically ensure that I am never going to progress any further in the game.