The Binding of Isaac is such a great game! I remember playing it near its release and literally couldn't put it down haha
I loved all of the interesting weapons and abilities you can acquire on each run. It makes it feel fresh and exciting each and every time you pick it up to play it.
It is a game that hooks you a lot hahaha.
I think that testing the combinations of the objects and trying them all is one of the most fun parts of this game without a doubt.