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Bleeding only happens when I work wet on wet with a good paper. Poor quality paper will bleed even when the bottom layer of paint is dry. I use an opaque watercolor called gouache. Also, I found quality paint is helpful. I prefer Winsor and Newton. Prisma ink pens will clog up going over Gouache and heavily pigmented watercolor paint, so I use posca pens to work on top of the color. I only used the Prisma pens on light pigmented objects.

I used black watercolor for the dewdrops. I work from light washes to dark and then use gouache paints. I don't have problems with precise shapes like dewdrops if I follow my rules.