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yes, im wondering spiritually what effect are they having.

I had to ask for guidance on that question. Not really. It can slow down spiritual evolution though, indirectly, because you mask pain, rather than feel and release it. Not all pain is down to an injury - much of the pain in our bodies is emotional and mental and needs to be released, not suppressed. Also, regular use stops people from changing their behaviour, which is spiritual. Our conscious choices are how we reflect spirit inside. In a way, over-use, addiction, or dependence are barriers to personal sovereignty. Another thing that came through is that painkillers can cause painful digestive issues that keep you in a vicious cycle.