Meanings could change, ambitions may take different shapes and structure and the size of your ambition could vary but the core value of ‘can do attitude’ should remain the same.
We mature, our tastes and preferences change, we experience new for better and worse - we can always be curious, we can always look for a better way, we can always discover more of who we are.
Yes. I meant that. You said it better :P :D
Curiosity is the key to have that 'can do' attitude irrespective of your age and situation. Once we lose that, the core behind your inquisitiveness is gone.