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In the film's gripping conclusion, Eliza Sue's fleeting existence hints at the futility of attempting to escape the natural cycle of life. As her grotesque form collapses into oblivion, only a cracked star on the Hollywood Walk of Fame remains to mark Elizabeth's trajectory—a poignant reminder of her lost glory and the price paid for pursuing an unattainable ideal.
"The Substance" is more than just a tale of horror; it’s a compelling commentary on fame, identity, and the unsustainable nature of personal reinvention through external validation. While Elizabeth's journey is fraught with despair, it serves as a cautionary tale about the human experience and our relentless chase for significance in a world obsessed with beauty and youth.