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Many medications, particularly non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen, can negatively impact kidney health when taken excessively over extended periods. Dr. Schusterman advises anyone with early-stage kidney disease to limit their use of NSAIDs and consult with a healthcare provider regarding their safety based on individual circumstances. In late-stage kidney disease, the avoidance of these medications may be crucial.