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In conclusion, the mass layoffs occurring within crucial health agencies under the Trump administration provoke grave concerns about the future of public health oversight in the United States. As Califf highlighted, dismantling essential staffing and expertise without a comprehensive plan poses an alarming risk to the nation's health, safety, and well-being. It is imperative that accountability and strategic management take precedence over merely cutting jobs in a bid to streamline government functions. The choices made today will resonate through the health of future generations, making thoughtful, informed discussion and action essential in addressing these critical issues.