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While the sitcom enjoyed popularity, it did face criticisms, particularly related to its premise: a wealthy white man adopting two children from Harlem. Following the show’s premiere, Bain reportedly received threats from the Ku Klux Klan, and cast member Todd Bridges also claimed harassment by individuals identifying as clan members.
Interestingly, the title Diff'rent Strokes was inspired by Muhammad Ali's famous phrase, helping to set the tone for a show that, while comedic, was not shy from addressing serious issues.