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Depends on what you're looking for of course, but Rome and Amsterdam are a couple of my favourites

What is something you shouldnt miss if you are in Amsterdam and the same for Rome in your opinion?

For me it's the overall experience rather than a specific thing to see or do, but check out these couple of threads for more:

(and search the LeoTravel community - https://inleo.io/communities/hive-190432 - for others)

https://inleo.io/threads/view/adambarratt/re-leothreads-gnurzpec

https://inleo.io/threads/view/adambarratt/re-leothreads-4ds9mv1n

For me it would have to be

Cant see which city you meant? Or do you think none is worth visiting? xP