The more advanced the civilization the harder it will be to kill off. I can't imagine what human technology will be like in 1000 years much less 100,000 years. Imagine AI with 1 million years to evolve.
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Ewoks defeated Palpatine's Stormtroopers. Taliban drove out USA military. Mujehadeen drove out USSR military.
Advancements in technology are not a given. There are periods of technological regression due to any number of factors.