Your lab still works on microRNA. What are you investigating? What questions do you still have?
One I find very interesting is a project where we collaborated with a clinician, a geneticist who studies intellectual disability. She had discovered that her patients, children with intellectual disabilities, in certain families carried a mutation that neither of their parents had – a spontaneous mutation – in the protein that is associated with microRNAs in humans called the Argonaute protein.
Each of our genomes contains four genes for Argonautes that are the partners of microRNAs. In fact, this is the effector protein that is guided by the microRNA to its target messenger RNAs. This Argonaute is what carries out the regulatory processes that happen once it finds its target.