Palestine Action, the group claiming responsibility, said protesters attacked the course "in response to the American administration's plans and threats to destroy, ethnically cleanse, and 'take over' the Gaza Strip, reports CNN.
They painted "GAZA IS NOT 4 SALE" on the lawn of the Turnberry resort and dug up parts of the golf course, including holes used in championship matches.
Palestine Action, a British-based activist group, says its goal is to disrupt the operations of weapons suppliers for the Israeli government.
Trump has said he wants to redevelop Gaza, and that the United States will "take over" the Gaza Strip.