It all depends on your tolerance. $100 makes the fees for dens around 0.5%, waiting longer makes the relative fee even smaller. To be honest, I would suggest waiting longer but I know people won't do it.
So let´s assume you want to harvest 5 CUBs in order to put them into the CUB den, then you have 2 times a fee of 0,25$.
Transaction fees have been over $0.50 until recently when they dropped to around $0.38.
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I know, as soon as you write something, it´s outdated!