World’s 1st donor cell therapy helps 3 autoimmune disorder patients in China
Three Chinese patients received treatment for autoimmune disorders using engineered immune cells made from donor cells. All three recipients reported improvements to their conditions. The treatment involved genetically engineering healthy-donor-derived CD19-targeting CAR-T cells using CRISPR-Cas9 to address issues with immune rejection. The study demonstrates the high safety and promising immune modularity effect of off-the-shelf CAR-T cells in treating severe refractory autoimmune diseases.