AI-Designed Enzymes
One of the ultimate aims of protein design is to build entirely new enzymes from scratch. Scientists have traditionally discovered enzymes in nature and then adapted them through trial and error. New advances in AI may eventually lead to ways to create bespoke enzymes from the ground up, but doing so remains a formidable challenge. Many of the protein structural databases used to train models consist overwhelmingly of structures gleaned from 'frozen' images, preventing them from making accurate recreations of dynamic structures.