I think compatibility is less of a problem than previously as USB interfaces need to be 'class compliant' to work with things like iPads. The problem can be when there are software only controls, but I have seen someone did a GUI for the Focusrites. I will test that when I get one and, of course, I will write it up on Hive.
Just found this that lists the DAWs you can use on Linux. They detail the pros and cons.
I think there are some other musicians using open source on Hive. Perhaps we need a community for that. You would think Hivers would favour open source solutions.
!BEER