I’ve heard for years that the clinical benefit range of those things is so narrow that most people have little to no benefit from them but end up getting the placebo effect more than anything.
It’s certainly a complicated problem in a day where things are so fast paced. I think unfortunately these things are going to lead to more invasive treatments in the future like brain implants to attempt to address it, yet cause crazy side effects.
Even still - are the people getting any exercise and outdoor exposure? Very often their issues are because those 2 scenarios are minimized.
I think it's a difference in the perspective on the way lay people vs people in health care see it. I know some claims about these stuff don't work on them but those claims can further be investigated as having unique cases where the drugs specifically don't work cause of their genes, drugs made in poor quality, non compliance, or resistance. A lot of possible reasons can come up when we're talking about why they don't work but if I were to just get the number from my own experience, I'd say out of 100 patients, there's going to be one that needs a bit of adjusting to their meds to work, given with these hypothetically numbers, would you say the meds don't work if they can't cater to that 1%? and 1% can mean 10 out of 1000 patients. I don't know, it just depends on how one frames it I guess.