Wow!! Life seem difficult during the 1800s especially with their belief in the theory of Humor where fluid, bile, and blood balancing was a thing. It is very difficult to make people change their mind but his was met with terrible actions. Now, we all wash our hands before doing anything without the knowledge that the story behind the practice was one of criticism, torture, and death.
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It is funny how we just say it casually now, making it look like it didn't pass through rigorous criticism and harsh process. At least today we know better to wash our hands regularly and it has saved a lot of lives.