Trimethylglycine
C5H11NO2
Inositol Niacinate
C42H30N6O12
Trigonelline
C7H7NO2
Trigonellinamide
C7H9N2O+
Nicotinamide
C6H6N2O
Niacin
C6H5NO2
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Trigonelline (TRL)
Trimethylglycine (TMG)
Trigonellinamide (MNA)
Trimethylamine (TMAO)
Dimethylsulfoxide (DMSO)
+1 Nitrogen Charge:
Trimethylglycine
Trigonellinamide
Trigonelline
Nucleotide
Salvage Pathway
MNA
Methylnicotinamide
Trigonellamide
Niacin
Betaine
DMSO/MSM
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N1-methylnicotinamide (Trigonellinamide) can be found abbreviated as MNA, meNAM, MNAM, or even NMN, creating inconsistency and confusion in the literature.
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SAMe
DAO
CoA
luteolin content. Scientists studying the effects of this polyphenol founds that it entirely abolished skin flushing (and entirely abolished the rise in serum Prostaglandin D2) in humans taking Niacin.
DAO, an enzyme that depends on Vitamin C, copper and magnesium, and via HNMT, which requires methylation).
nicotinic acid, inositol hexaniacinate and niacinamide.
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Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia
https://www.nature.com/articles/s42255-024-00997-x
Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30190-X
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S-adenosyl-l-homocysteine (SAH)
CD38 Inhibitor 1
NNMT
CD38
PARP
Sirtuin
MTHFR
Trimethylamine
Trimethylamine N-Oxide
https://en.m.wikipedia.org/wiki/NNMT
https://en.m.wikipedia.org/wiki/CD38
https://en.m.wikipedia.org/wiki/CD38-IN-78c
https://en.m.wikipedia.org/wiki/Nucleotide_salvage
..
Complex roles of nicotinamide N-methyltransferase in cancer progression
https://www.nature.com/articles/s41419-022-04713-z
Nicotinamide N-methyltransferase (NNMT) is an S-adenosyl-l-methionine (SAM)-dependent cytosolic enzyme. Taking SAM as the methyl donor, NNMT catalyzes N-methylation of nicotinamide (NAM) to generate 1-methylnicotinamide (1-MNAM) and S-adenosyl-l-homocysteine (SAH).
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https://en.m.wikipedia.org/wiki/Trimethylamine
https://en.m.wikipedia.org/wiki/Trimethylamine_N-oxide
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DMSO and TMAO
Differences in Interactions in Aqueous Solutions of the K-Peptide
NAD+ vs. NADH
https://www.nad.com/nad-vs-nadh
NADH carries the electrons gained from the breakdown of glucose and donates them to the chain of enzymes in mitochondria that are involved in producing ATP (electron transport chain). This oxidizes NADH back to NAD+. Ultimately, the energy from the electrons donated by NADH is exploited by mitochondria to produce ATP (oxidative phosphorylation).
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figured it out, the + on the Nitrogen just means it already Methylated and capable of transporting Hydrogen & manufacturing NAD+ NADH Hydrogen transport into ATP.
the + is a little hand that grabs Hydrogen & drops it off.
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Nicotinamide N-methyltransferase: At the crossroads between cellular metabolism and epigenetic regulation
https://pmc.ncbi.nlm.nih.gov/articles/PMC7868988/
Source of nicotinamide governs its metabolic fate in cultured cells, mice, and humans
https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00229-2