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The film opens in the secluded home of the Holmes family, where young Enola lives with her eccentric mother, Eudoria. After the death of their father and the departure of her older brothers, the household has become a woman-centric domain, deeply influenced by Eudoria's unconventional parenting style. Enola, whose name humorously spells "alone" backward, has been educated in various disciplines including science, literature, and even self-defense, preparing her to be fiercely independent.