The only base assumption in science is that the universe is consistent. From that core assumption we can make observations and verify postulates. Yes things change in Science and that is great but Science doesn't assume any postulates to be true without verification. This process of verification gave rise to quantum mechanics not through just postulation. The verification is important no postulate is considered true until tested.
The single core assumption remains the same the rest is built on observation.
To me, stating that the universe is consistent does not mean anything. Sorry.
Universe is consistent makes all kinds of sense. When someone says it does not mean anything, I can only guess that English isn't their fluent language.
Nice post by the way.