The ones that are family, at least in your heart and soul, are always the ones that we allow to impact how we feel, because we've let them come so close to our inner core.
At the end of the day, you're the only one living your life. I have blood family and even best friends that I consider family, that I wish they would reach out to me more often, or try to better themselves, or just generally live happier lives. We can't control anything or anyone outside of our own minds, bodies, and souls.
If the people that you consider family doesn't approve of the person you are or treat you differently because of it, then that's on them. As long as you aren't personally harming them or causing them any turmoil through direct actions, and they're only acting differently towards you because of your personality - that's their prerogative.
Do you, live your life, and be the best "you" that you can be. Naturally, you'll attract those that see the beauty of who you really are, and become people in your life that matter.
I'm closer to some people I've met while traveling than I am with some of my own blood relatives - simply because of the lifestyle I live. You can't let that get to you emotionally or mentally, however disconcerting it may be.