The results of a study by a Bahraini medical team have revealed new proteins in patients with multiple sclerosis, which help determine the response to treatment, to provide the appropriate dose of treatment, and published the results of this study in the Journal of Multiple Sclerosis and related disorders. The study examined blood samples from 88 Bahraini patients suffering from MS, 88 others. The study included the examination of genetic expression by microarray, which is one of the latest techniques for the analysis of genetic mutations in the human genome, and the examination of the properties of molecules affecting the active genes through the enzyme linked to the immune The examiner
The research team included: Dr. Issa Al-Shorouki, Neurology Consultant at Salmaniya Medical Complex, Dr. Moudhi Al Nashmi, and Dr. Safa Taha from Princess Al Jawhara Center. Dr. Moez Bakhit, director of the Center for Gemology, said that the data showed that there were 5 genes that were significantly higher in patients with MS compared to the control group. "The analysis of the transponder molecules from the genes revealed that there were two Of the immune proteins produced by these five genes are high in patients,So that they can be considered vital indicators associated with the inflammatory process of the disease and contribute to the determination of response treatment in Bahraini patients. Dr. Bakhit said the results of the research will be announced at international conferences such as the third annual conference of the American Committee for Treatment and Research in Multiple Sclerosis (ACTRMS) in February.
Dr. Bakhit explained that multiple sclerosis is one of the diseases of the nervous system, a multifocal disease remover of myelin, and is associated with advanced neurodegeneration, as the immune system produces anti-membrane surrounding the nerves, which leads to the destruction, which negatively affects the process of communication between The brain and the rest of the body.
The symptoms of MS appear according to the location of damage to the nervous system, and may include loss of sensation, acupuncture, numbness, numbness, muscle weakness, muscular stiffness with difficulty of movement, coordination, loss of balance, speech disorder, difficulty swallowing, vision problems caused by optic neuritis And double vision
As well as severe fatigue and acute or chronic pain, and bladder and intestinal problems, as well as accompanied by the disease difficulties in thinking and some psychological problems such as depression and mood swings. According to the research team, the disease is caused by the damage of plaques in the brain and spinal cord, and affects adults age without known causes. The study aims at helping to determine the degree of response to treatment to achieve the principles of personal medicine, which aims to provide appropriate treatment at the right dose at the right time.
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