I personally have never had a huge issue with my weight. I have usually been on the higher BMI side of normal but recently I have lost a good amount of weight and am on the lower side. I feel much better and happier overall. It is a shame that this gene exists. Although I believe anything is possible with enough effort.
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I feel so much better too - and I can really feel it when I put weight back on. And I don't like the feeling... Thanks purpleblob!