I'm with you here @thedarkhorse, My house is equally cluttered, although not quite up to an episode of Hoarders!
My problem is it's the wife's stuff and not mine. Getting her to shed it is like pulling teeth. What's real junk and what's sellable, its a big task I tell ya!
Do a little reading on the topic of clutter and the stress it causes. Then share the articles with your Wife and see if she can wrap her head around clearing out 1 room. For most they say start with the smallest project first and then move forward. I had a need to make my office clear so I went after one of the worst rooms first, but it's not suggested to go this direction. Heck even clearing out your "junk drawer" is a big mental step. I just did that too as I wanted to keep getting more done.