If there is anything I have learned about drugs, it is that there is always a reactionary, rebalancing effect. Beyond the monetary aspects, when you use a drug to remedy an issue, or for recreational purposes, as soon as you stop, your body will seek to bring itself back to neutral by swinging the pendulum way the other way. A friend of mine would describe it as "borrowed happiness, to be repaid...with interest."
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Depends on the drug but with most drugs of abuse there is the issue of tolerance and withdrawal reactions.