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This is the best part! You simply download their software and it determines the best mining software to use for the specific desired currency for profitability at the time. It takes care of everything on the fly behind the scenes now that the miner is configured properly- although a bit of Windows configuration was necessary for optimal results. I just set it and forget it now.

That is a great feature, and its pays out in btc right?
Have you rented or rented out at all? I like the idea of renting machines.
You could get paid up front to run a system part time, then have it working for yourself the remaining time.
Or rent a dozen or so at once to powermine the newer coins.

It does pay out in BTC but only thing I'd mention is to have Nicehash point your earnings towards your own address to avoid their transaction fees for using their BTC wallet. I haven't tried renting but I love the idea of mining the new coins now. One of my favorites is Sia coin!