Excitotoxicity is physiological. While certain psychological things might cause behaviors that could put you at risk, there are far more subtle implications of excitotoxic cell death purely from psychologcial states. There is however, reason to believe that chronic stress can cause mPFC excitotoxicity. I will be writing an article in the near future about one example of this which involves anxiety and fear like behavior causing neurodegeneration via cholinergic modulators in rats, and a current study in humans. Be sure to look out for it!
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