First lets start with what depression means :
A mental state characterized by a pessimistic sense of inadequacy and a despondent lack of activity.
its just a state of the mind and only the mind can actual cure depression.
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It depends on what type of depression... some people have a permanent imbalance. I've had suicidal thoughts my whole life since I was 4, no matter how good or bad things were. Venlafaxine fixed that for me literally in hours.
But for the vast majority of people that's true.