The latest market report published by Credence Research, Inc. “Mantle Cell Lymphoma Treatment Market - Growth, Future Prospects, Competitive Analysis, 2017 - 2025,” the global mantle cell lymphoma treatment market is set to grow at a CAGR of 4.8 % from 2017 to 2025.
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Market Insights
It is very important in patients suffering with lymphoma cancer to identify the subtype during diagnosis, as the treatment usually depends on that particular subtype. Common biomarkers of mantle cell lymphoma are overexpression of cyclin D1 proteins, reciprocal translocation observed in chromosomes 11 and 14 and CD20 antigen as a surface marker on the B cells. As majority of the patients undergoing aggressive chemotherapy have shown disease relapse the USFDA has designed the treatment regimen for the durable treatment of mantle cell lymphoma. R-CHOP is a combination therapy consisting of rituximab in combination with doxorubicin, cyclophosphamide, prednisone and vincristine is preferred with autologous stem cell transplant to resist disease relapse. VcR-CHOP comprising of bortezomib, cyclophosphamide, rituxan, doxorubicin, vincristine and prednisone is prescribed for patients previously not treated for mantle cell lymphoma.
Rituximab is considered as the first line of treatment by USFDA either as a monotherapy or in combination with other chemotherapy drugs; its ability to bind to CD20 antigen present on the cell surface of B cells and destroys the tumor cells by apoptosis. This makes rituximab the most efficient drug in the treatment of mantle cell lymphoma. Increasing cases of relapsed mantle cell lymphoma and its drug compatibility with the chemotherapy drugs used as adjuvants in the dosage regimen contributes towards the significant market growth of ibrutinib. It is noteworthy to notice that in 2020 generic competition will be faced by lenalidomide and bortezomib.
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Rising prevalence of mantle cell lymphoma and the domicile of pharmaceutical companies with promising product pipeline has resulted in the dominance of North America in the global mantel cell lymphoma treatment market. Asia Pacific highlights an attractive market destination for the treatment of mantle cell lymphoma due to developing healthcare infrastructure, rampant growth in multispecialty clinic diagnosing, and treating mantle cell lymphoma.
The mantle cell lymphoma treatment market includes major players such as F.Hoffman La Roche Ltd., Abbvie, Inc., Astellas Pharma, Inc., Biogen, Inc., Bayer AG, Bristol-Myers Squibb Company, Celgene Corporation, Eli Lilly and Company, GlaxoSmithKline Plc, Amgen, Inc., Gilead Sciences, Inc. and Johnson and Johnson.
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Key Market Movements:
Technological advancement in the diagnostic procedures has identified more number of mantle cell lymphoma cases in non-Hodgkin’s lymphoma patients.
Increasing research and development activities in the healthcare sector has resulted in a promising product pipeline
Regulatory agencies providing supportive environment to expedite the drug approval for treatment of mantle cell lymphoma
TOC :
Chapter 3. Mantle Cell Lymphoma Treatment Market: Dynamics and Future Outlook
3.1. Market Overview
3.2. Drivers
3.3. Challenges
3.4. Opportunities
3.5. Attractive Investment Proposition, by Geography
3.6. Top 3 Countries: Global Mantle Cell Lymphoma Treatment Market, 2015-2025 (US$ Mn)
3.7. Competitive Landscape: Global Mantle Cell Lymphoma Treatment Market, by Key Players, 2015-2025 (US$ Mn)
Chapter 4. Global Mantle Cell Lymphoma Treatment Market, by Mechanism of Action, 2015 – 2025 (US$ Mn)
4.1. Overview
4.2. Attractive Investment Proposition: Global Mantle Cell Lymphoma Treatment Market, by Mechanism of Action, 2016
4.3. Bruton’s Tyrosine Kinase Blocker (Ibrutinib)
4.4. Angiogenesis Inhibitor (Lenalidomide)
4.5. CD20 Antigen Inhibitor (Rituximab)
4.6. mTOR Protein Inhibitor (Temsirolimus)
4.7. Proteasome Inhibitors (Bortezomib)
4.8. Phase III Drug
4.8.1. Acalabrutinib
4.8.2. Bendamustine/Rituximab/Ibrutinib (Qualitative Information)
4.8.3. Ibrutinib/Venetoclax (Qualitative Information)
4.8.4. Lenalidomide/Rituximab (Qualitative Information)
4.8.5. Rituximab/Bortezomib (Qualitative Information)
4.9. Tabular Representation of Phase II and I Drugs
Chapter 5. Global Mantle Cell Lymphoma Treatment Market, by Geography, 2015 – 2025 (US$ Mn)
5.1. Overview
5.2. North America Mantle Cell Lymphoma Treatment Market Analysis, 2015 – 2025
5.2.1. North America Mantle Cell Lymphoma Treatment Market, by Mechanism of Action, 2015 – 2025 (US$ Mn)
5.2.2. North America Mantle Cell Lymphoma Treatment Market, by Country, 2015 – 2025 (US$ Mn)
5.3. Europe Mantle Cell Lymphoma Treatment Market Analysis, 2015 – 2025
5.3.1. Europe Mantle Cell Lymphoma Treatment Market, by Mechanism of Action, 2015 – 2025 (US$ Mn)
5.3.2. Europe Mantle Cell Lymphoma Treatment Market, by Country, 2015 – 2025 (US$ Mn)
5.4. Asia Pacific Mantle Cell Lymphoma Treatment Market Analysis, 2015 – 2025
5.4.1. Asia Pacific Mantle Cell Lymphoma Treatment Market, by Mechanism of Action, 2015 – 2025 (US$ Mn)
5.4.2. Asia Pacific Mantle Cell Lymphoma Treatment Market, by Country, 2015 – 2025 (US$ Mn)
5.5. Latin America Mantle Cell Lymphoma Treatment Market Analysis, 2015 – 2025
5.5.1. Latin America Mantle Cell Lymphoma Treatment Market, by Mechanism of Action, 2015 – 2025 (US$ Mn)
5.5.2. Latin America Mantle Cell Lymphoma Treatment Market, by Country, 2015 – 2025 (US$ Mn)
5.6. Middle East & Africa Mantle Cell Lymphoma Treatment Market Analysis, 2015 – 2025
5.6.1. Middle East and Africa Mantle Cell Lymphoma Treatment Market, by Mechanism of Action, 2015 – 2025 (US$ Mn)
5.6.2. Middle East and Africa Mantle Cell Lymphoma Treatment Market, by Region, 2015 – 2025 (US$ Mn)
Chapter 6. Company Profiles
6.1. Abbvie, Inc.
6.1.1. Business Description
6.1.2. Financial Information (Subject to data availability)
6.1.3. Product Portfolio
6.1.4. Key Developments
6.2. Amgen, Inc.
6.3. Astellas Pharma, Inc.
6.4. Biogen, Inc.
6.5. Bayer AG
6.6. Bristol-Myers Squibb Company
6.7. Celgene Corporation
6.8. Eli Lilly and Company
6.9. GlaxoSmithKline Plc
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