I don't see how this disproves the simulation hypothesis. At most, it simply means that it's impossible to precisely simulate the entire universe in sufficient detail to trick the simulated intelligences within that their reality is a simulation.
Honestly, you don't need to simulate the entire universe. Really and truly, how much of the universe have we explored in any great detail? That, I think, is eminently achievable and could be achieved within our lifetimes.