Love Schmidhuber!
To my mind the most interesting questions are those that cut to the heart of the existing world-view framework. So, unless threatened, one should go directly to things like philosophy, science and information-theory and ask systematic questions there to challenge ones overall view of the world and update it to be able to predict everything that happens. This will also allow one to create anything and travel anywhere.
Posted about some of Schmidhuber's other ideas here :)